Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm.

ABSTRACT:

Aims

Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows considerable promise for the treatment of TLE. However, the optimal stimulation targets and parameters of DBS to control seizures and related cognitive impairment are still not fully illustrated.

Methods

In the present study, we evaluated the therapeutic potential of DBS in the medial septum (MS) on seizures and cognitive function in mouse acute and chronic epilepsy models.

Results

We found that DBS in the MS alleviated the severity of seizure activities in both kainic acid-induced acute seizure model and hippocampal-kindled epilepsy model. DBS showed antiseizure effects with a wide window o

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8025637 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature