A neural substrate for behavioral inhibition in the risk for major depressive disorder.

ABSTRACT:

Objective

Behavioral inhibition (BI) is an early developing trait associated with cautiousness and development of clinical depression and anxiety. Little is known about the neural basis of BI and its predictive importance concerning risk for internalizing disorders. We looked at functional connectivity of the default-mode network (DMN) and salience network (SN), given their respective roles in self-relational and threat processing, in the risk for internalizing disorders, with an emphasis on determining the functional significance of these networks for BI.

Method

We used functional magnetic resonance imaging to scan, during the resting state, children and adolescents 8 to 17 years of age who were either at high familial risk (HR; n = 16) or low familial risk (LR; n = 18) for

SUBMITTER: Frost Bellgowan J 

PROVIDER: S-EPMC8025660 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature