Nanofibrous Tubular Three-Dimensional Platform for Single Dental Pulp Stem Cell Polarization.

ABSTRACT: Dental pulp stem cells (DPSCs) are the primary stem cell source for regenerative endodontics. DPSCs need to undergo a polarization process and retain the permanent polarization status to perform the function of odontoblasts. However, the factors that control DPSC polarization and its underlying mechanism remain unknown. In this study, we established a unique nanofibrous tubular three-dimensional (3D) platform to explore DPSC polarization. The 3D platform has a "clean" background and confines one single DPSC in each microisland of the platform; therefore, it is capable of deciphering any signal that initiates or regulates DPSC polarization. Using the biomimetic platform, we identified that the nanofibrous tubular architecture is the crucial factor to initiate DPSC polarization. Dynamic morp

SUBMITTER: Chang B 

PROVIDER: S-EPMC8025693 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature