Formation and regeneration of a Wnt-responsive junctional epithelium.

ABSTRACT:

Aim

To identify the molecular mechanisms mediating the persistent defensive functions of the self-renewing junctional epithelium (JE).

Materials and methods

Two strains of Wnt reporter mice, Axin2^{CreErt2 /+} ;R26R^{mTmG /+} and Axin2^{LacZ /+} , were employed, along with three clinically relevant experimental scenarios where the function of the JE is disrupted: after tooth extraction, after a partial gingivectomy, and after a complete circumferential gingivectomy.

Results

Using transgenic Wnt reporter strains of mice, we established the JE is a Wnt-responsive epithelium beginning at the time of its formation and that it maintains this status into adulthood. After tooth extraction, progeny of the initial Wnt-re

SUBMITTER: Yuan X 

PROVIDER: S-EPMC8025694 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature