Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water.

ABSTRACT: Deuterium-labeled nicotinamide cofactors such as [4-²H]-NADH can be used as mechanistic probes in biological redox processes and offer a route to the synthesis of selectively [²H] labeled chemicals via biocatalytic reductive deuteration. Atom-efficient routes to the formation and recycling of [4-²H]-NADH are therefore highly desirable but require careful design in order to alleviate the requirement for [²H]-labeled reducing agents. In this work, we explore a suite of electrode or hydrogen gas driven catalyst systems for the generation of [4-²H]-NADH and consider their use for driving reductive deuteration reactions. Catalysts are evaluated for their chemoselectivity, stereoselectivity, and isotopic selectivity, and it is shown t

SUBMITTER: Rowbotham JS 

PROVIDER: S-EPMC8025731 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature