Dataset Information
Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk.
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ABSTRACT:
SUBMITTER: Vaura F
PROVIDER: S-EPMC8025831 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk.
Hypertension (Dallas, Tex. : 1979) 20210222 4
Although genetic risk scores have been used to predict hypertension, their utility in the clinical setting remains uncertain. Our study comprised N=218 792 FinnGen participants (mean age 58 years, 56% women) and N=22 624 well-phenotyped FINRISK participants (mean age 50 years, 53% women). We used public genome-wide association data to compute polygenic risk scores (PRSs) for systolic and diastolic blood pressure (BP). Using time-to-event analysis, we then assessed (1) the association of BP PRSs ...[more]