Crystal structure of <i>tert</i>-butyl 4-[4-(4-fluoro-phen-yl)-2-methyl-but-3-yn-2-yl]piperazine-1-carboxyl-ate.

ABSTRACT: The title sterically congested piperazine derivative, C₂₀H₂₇FN₂O₂, was prepared using a modified Bruylants approach. A search of the Cambridge Structural Database identified 51 compounds possessing an N-tert-butyl piperazine substructure. Of these only 14 were asymmetrically substituted on the piperazine ring and none with a synthetically useful second nitro-gen. Given the novel chemistry generating a pharmacologically useful core, determination of the crystal structure for this compound was necessary. The piperazine ring is present in a chair conformation with di-equatorial substitution. Of the two N atoms, one is sp ³ hybridized while the other is sp ² hybridized. Inter-molecular inter-actions resultin

SUBMITTER: Gumireddy A 

PROVIDER: S-EPMC8025862 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature