A Set of Six Gene Expression Biomarkers Identify Rat Liver Tumorigens in Short-term Assays.

ABSTRACT: Chemical-induced liver cancer occurs in rodents through well-characterized adverse outcome pathways. We hypothesized that measurement of the 6 most common molecular initiating events (MIEs) in liver cancer adverse outcome pathways in short-term assays using only gene expression will allow early identification of chemicals and their associated doses that are likely to be tumorigenic in the liver in 2-year bioassays. We tested this hypothesis using transcript data from a rat liver microarray compendium consisting of 2013 comparisons of 146 chemicals administered at doses with previously established effects on rat liver tumor induction. Five MIEs were measured using previously characterized gene expression biomarkers composed of gene sets predictive for genotoxicity and activation of 1 or mor

SUBMITTER: Corton JC 

PROVIDER: S-EPMC8026143 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature