Management of Acute Myeloid Leukemia (AML) in Older Patients.

ABSTRACT:

Purpose of review

The acute myeloid leukemia (AML) treatment landscape has rapidly evolved over the past few years. These changes have several implications for the care of older adults (≥ 60 years), who have inferior clinical outcomes. We review decision-making in older adults, focusing on patient- and disease-related factors. We then summarize current treatment options, including multiple recently approved therapies, based on hypothetical clinical scenarios.

Recent findings

In lieu of using chronological age to determine fitness, we highlight the importance of standardized fitness assessments using geriatric assessments. Next, we review intensive and lower-intensity treatment options in the upfront setting. We focus on multiple newly approved medications, including venetocl

SUBMITTER: Abdallah M 

PROVIDER: S-EPMC8026174 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature