Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma.

ABSTRACT: The role of PPAR gamma (PPARγ) has been well characterized in the developmental process of adipogenesis, yet its aberrant expression patterns and functions in cancer subtypes are less understood. Although PPARγ has been recently demonstrated to play non-cell-autonomous roles in promoting bladder urothelial carcinoma (UC) progression, underlying mechanisms of the cell-intrinsic oncogenic activity remain unknown. Here, we report robust expression and nuclear accumulation of PPARγ in 47% of samples of patients with UC, exceeding mRNA expression patterns published by The Cancer Genome Atlas. In vitro assays revealed for the first time that treatment of UC cells with PPARγ inverse agonist or PPARG knockout by CRISPR-Cas9 reduces proliferation, migration, and invasion of multiple e

SUBMITTER: Sanchez DJ 

PROVIDER: S-EPMC8026526 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature