High-intensity ultrasound catheter ablation achieves deep mid-myocardial lesions in vivo.

ABSTRACT:

Background

Radiofrequency ablation of epicardial and mid-myocardial ventricular arrhythmias is limited by lesion depth.

Objective

The purpose of this study was to generate deep mid-interventricular septal (IVS) lesions using high-intensity ultrasound (US) from an endocardial catheter-based approach.

Methods

Irrigated US catheters (12 F) were fabricated with 3 × 5 mm transducers of 5.0, 6.5, and 8.0 MHz frequencies and compared in an ex vivo perfused myocardial ablation model. In vivo septal ablation in swine (n = 12) was performed via femoral venous access to the right ventricle. Lesions were characterized by echocardiography, cardiac magnetic resonance imaging, and electroanatomic voltage mapping pre- and post-ablation, and at 30 days. Four animals were euthanized im

SUBMITTER: Nazer B 

PROVIDER: S-EPMC8026528 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature