Cessation classification likelihood increases with higher expired-air carbon monoxide cutoffs: a meta-analysis.

ABSTRACT:

Background

Expired-air carbon monoxide (CO) is commonly used to biochemically verify smoking status. The CO cutoff and CO monitor brand may affect the probability of classifying smokers as abstinent, thus influencing conclusions about the efficacy of cessation trials. No systematic reviews have tested this hypothesis. Therefore, we performed a meta-analysis examining whether the likelihood of smoking cessation classification varied due to CO cutoff and monitor brand.

Methods

Eligible studies (k = 122) longitudinally assessed CO-verified cessation in adult smokers in randomized trials. Primary meta-regressions separately assessed differences in quit classification likelihood due to continuous and categorical CO cutoffs (Low, 3-4 parts per million [ppm]; [SRNT] Recommended, 5-

SUBMITTER: Karelitz JL 

PROVIDER: S-EPMC8026538 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature