Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias.

ABSTRACT: Patients with myelodysplastic syndromes (MDSs) display severe anemia but the mechanisms underlying this phenotype are incompletely understood. Right open-reading-frame kinase 2 (RIOK2) encodes a protein kinase located at 5q15, a region frequently lost in patients with MDS del(5q). Here we show that hematopoietic cell-specific haploinsufficient deletion of Riok2 (Riok2^f/+Vav1^cre) led to reduced erythroid precursor frequency leading to anemia. Proteomic analysis of Riok2^f/+Vav1^cre erythroid precursors suggested immune system activation, and transcriptomic analysis revealed an increase in p53-dependent interleukin (IL)-22 in Riok2^f/+Vav1^cre CD4⁺ T cells (T_H22). Further, we discovered that the IL-22 recepto

SUBMITTER: Raundhal M 

PROVIDER: S-EPMC8026551 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature