Brain morphological abnormalities in children with cyclin-dependent kinase-like 5 deficiency disorder.

ABSTRACT:

Background

To quantitatively evaluate the brain MRI morphological abnormalities in patients with cyclin-dependent kinase-like 5 deficiency disorder (CDD) on a group level and longitudinally.

Methods

We performed surface-based MRI analysis on high-resolution T1-weighted images on three CDD patients scanned at age of three years, and compared with 12 age- and gender-matched healthy controls. We further examined the longitudinal morphological changes in one patient with a follow-up of 5 years.

Results

CDD patients presented significant reductions in total intracranial volume, total gray matter (GM) volume and subcortical GM volume compared to controls. For subcortical regions, significant GM volume reductions were seen in the brain stem, bilateral thalamus, bilateral hip

SUBMITTER: Tang Y 

PROVIDER: S-EPMC8026562 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature