Evaluation of the Addictions Neuroclinical Assessment (ANA) framework through deep phenotyping of problem drinkers.

ABSTRACT:

Background

To advance the development of a neuroscience-informed understanding of alcohol use disorder (AUD) through the Addictions Neuroclinical Assessment (ANA) framework, the present study reports on deep phenotyping of a large sample of problem drinkers.

Methods

Participants (n = 1679) were primarily heavy drinkers with and without AUD, who completed a phenotypic battery of well-validated scales and behavioral measures of alcohol use and problems, mood, attention, and impulsivity. These scales were subjected to sequential factor analytic work in order to derive a factor solution that explains biobehavioral variation in the sample. To assess the construct validity of the resulting factor solution, scores on each factor were associated with demographic and clinical indicat

SUBMITTER: Nieto SJ 

PROVIDER: S-EPMC8026564 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature