Echocardiographic Molecular Imaging of the Effect of Anticytokine Therapy for Atherosclerosis.

ABSTRACT:

Background

Echocardiographic molecular imaging techniques are beginning to be applied to evaluate preclinical efficacy of new drugs. In a large clinical trial, anti-interleukin-1β (IL-1β) immunotherapy reduced atherosclerotic events, yet treatment effects were modest, and the mechanisms of action were not fully elucidated. We tested the hypothesis that echocardiographic molecular imaging can assess changes in vascular thromboinflammatory status in response to anti-IL-1β therapy.

Methods

In wild-type and atherosclerotic mice deficient for the low-density lipoprotein-receptor and Apobec-1, closed-chest myocardial infarction (MI) was performed to mimic high-risk clinical cohorts. Control animals had sham surgery. Post-MI animals were randomized to either no therapy or anti-IL-1

SUBMITTER: Shentu W 

PROVIDER: S-EPMC8026579 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature