Racial differences in platelet serotonin polymorphisms in acute coronary syndrome.

ABSTRACT:

Introduction

Genetic differences between races have been hypothesized to contribute to differences in outcome from acute coronary syndromes (ACS). Our objective was to assess racial differences in genetic variations in the platelet serotonin transporter (5HTT) and receptor in patients with ACS.

Materials and methods

127 consecutive patients, African Americans (AA) = 27; Caucasian (C) =100, admitted with ACS were evaluated for platelet function by serotonin (5HT) induced platelet activation. All patients were genotyped for two polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) S/L and L_G/L_A and one polymorphism of the serotonin 2A receptor (5-HT2A, T102C) gene. All patients were followed for major and minor adverse cardiac ev

SUBMITTER: Williams MS 

PROVIDER: S-EPMC8026585 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature