Secular Trends in Breast Cancer Risk Among Women With HIV Initiating ART in North America.

ABSTRACT:

Background

Studies suggest lower risk of breast cancer in women with HIV versus without HIV. These estimates may be biased by lower life expectancy and younger age distribution of women with HIV. Our analysis evaluated this bias and characterized secular trends in breast cancer among women with HIV initiating antiretroviral therapy. We hypothesized breast cancer risk would increase over time as mortality decreased.

Setting

Women with HIV prescribed antiretroviral therapy in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) from 1997 through 2016.

Methods

We estimated breast cancer hazard (cause-specific hazard ratios) and cumulative incidence accounting for competing risks (subdistribution hazard ratios) to assess changes in breast cancer

SUBMITTER: Coburn SB 

PROVIDER: S-EPMC8026587 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature