Distinct temporal actions of different types of unfolded protein responses during aging.

ABSTRACT: Proteotoxic stress is a common challenge for all organisms. Among various mechanisms involved in defending such stress, the evolutionarily conserved unfolded protein responses (UPRs) play a key role across species. Interestingly, UPRs can occur in different subcellular compartments including the endoplasmic reticulum (UPR^ER ), mitochondria (UPR^MITO ), and cytoplasm (UPR^CYTO ) through distinct mechanisms. While previous studies have shown that the UPRs are intuitively linked to organismal aging, a systematic assay on the temporal regulation of different type of UPRs during aging is still lacking. Here, using Caenorhabditis elegans (C. elegans) as the model system, we found that the endogenous UPRs (UPR^ER , UPR^MITO , and UPR^CYTO

SUBMITTER: Sheng Y 

PROVIDER: S-EPMC8026671 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature