Smoking-induced craving relief relates to increased DLPFC-striatal coupling in nicotine-dependent women.

ABSTRACT:

Background

Craving is a major contributor to drug-seeking and relapse. Although the ventral striatum (VS) is a primary neural correlate of craving, strategies aimed at manipulating VS function have not resulted in efficacious treatments. This incongruity may be because the VS does not influence craving in isolation. Instead, craving is likely mediated by communication between the VS and other neural substrates. Thus, we examined how striatal functional connectivity (FC) with key nodes of networks involved in addiction affects relief of craving, which is an important step in identifying viable treatment targets.

Methods

Twenty-four nicotine-dependent non-abstinent women completed two resting-state (rs) fMRI scans, one before and one following smoking a cigarette in the scanne

SUBMITTER: Franklin TR 

PROVIDER: S-EPMC8026729 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature