Manganese dioxide nanosheets induce mitochondrial toxicity in fish gill epithelial cells.

ABSTRACT: The development and production of engineered 2D nanomaterials are expanding exponentially, increasing the risk of their release into the aquatic environment. A recent study showed 2D MnO₂ nanosheets, under development for energy and biomedical applications, dissolve upon interaction with biological reducing agents, resulting in depletion of intracellular glutathione levels within fish gill cells. However, little is known concerning their toxicity and interactions with subcellular organelles. To address this gap, we examined cellular uptake, cytotoxicity and mitochondrial effects of 2D MnO₂ nanosheets using an in vitro fish gill cell line to represent a target tissue of rainbow trout, a freshwater indicator species. The data demonstrate cellular uptake of MnO

SUBMITTER: Browning CL 

PROVIDER: S-EPMC8026737 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature