Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence.

ABSTRACT:

Purpose

To investigate the role of consumption phenotypes as genetic proxies for alcohol misuse and nicotine dependence.

Methods

We leveraged GWAS data from well-powered studies of consumption, alcohol misuse, and nicotine dependence phenotypes measured in individuals of European ancestry from the UK Biobank (UKB) and other population-based cohorts (largest total N = 263,954), and performed genetic correlations within a medical-center cohort, BioVU (N = 66,915). For alcohol, we used quantitative measures of consumption and misuse via AUDIT from UKB. For smoking, we used cigarettes per day from UKB and non-UKB cohorts comprising the GSCAN consortium, and nicotine dependence via ICD codes from UKB and Fagerström Test for Nicotine Dependence from non-UKB cohorts.

Results

SUBMITTER: Sanchez-Roige S 

PROVIDER: S-EPMC8026738 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature