Epigenome-wide study of brain DNA methylation following acute opioid intoxication.

ABSTRACT:

Background

Opioid abuse poses significant risk to individuals in the United States and epigenetic changes are a leading potential biomarker of opioid abuse. Current evidence, however, is mostly limited to candidate gene analysis in whole blood. To clarify the association between opioid abuse and DNA methylation, we conducted an epigenome-wide analysis of DNA methylation in brain samples of individuals who died from acute opioid intoxication and group-matched controls.

Methods

Tissue samples were extracted from the dorsolateral prefrontal cortex of 153 deceased individuals (M_age = 35.42; 62 % male; 77 % European ancestry). The study included 72 opioid samples, 53 psychiatric controls, and 28 normal controls. The epigenome-wide analysis was implemented using the Ill

SUBMITTER: Shu C 

PROVIDER: S-EPMC8026744 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature