Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia.

ABSTRACT:

Objectives

To understand the differential neuroanatomical substrates underlying apathy and depression in Frontotemporal dementia (FTD).

Methods

T1-MRIs and clinical data of patients with behavioral and aphasic variants of FTD were obtained from an open database. Cortical thickness was derived, its association with apathy severity and difference between the depressed and not depressed were examined with appropriate covariates.

Results

Apathy severity was significantly associated with cortical thinning of the lateral parts of the right sided frontal, temporal and parietal lobes. The right sided orbitofrontal, parsorbitalis and rostral anterior cingulate cortex were thicker in depressed compared to patients not depressed.

Conclusions

Greater thickness of right sid

SUBMITTER: Basavaraju R 

PROVIDER: S-EPMC8026775 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature