Mitochondrial Reactive Oxygen Species Regulate Immune Responses of Macrophages to <i>Aspergillus fumigatus</i>.

ABSTRACT: Reactive Oxygen Species (ROS) are highly reactive molecules that can induce oxidative stress. For instance, the oxidative burst of immune cells is well known for its ability to inhibit the growth of invading pathogens. However, ROS also mediate redox signalling, which is important for the regulation of antimicrobial immunity. Here, we report a crucial role of mitochondrial ROS (mitoROS) in antifungal responses of macrophages. We show that mitoROS production rises in murine macrophages exposed to swollen conidia of the fungal pathogen Aspergillus fumigatus compared to untreated macrophages, or those treated with resting conidia. Furthermore, the exposure of macrophages to swollen conidia increases the activity of complex II of the respiratory chain and raises mitochondrial membrane p

SUBMITTER: Hatinguais R 

PROVIDER: S-EPMC8026890 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature