Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis.

ABSTRACT:

Background

Emerging oncogenes were reportedly linked to the complicated subtypes and pathogenesis of clinical gliomas. Herein, we first comprehensively explored the potential correlation between growth-arrest-specific two family genes (GAS2, GAS2L1, GAS2L2, GAS2L3) and gliomas by bioinformatics analysis and cellular experiments.

Methods

Based on the available datasets of TCGA (The Cancer Genome Atlas), CGGA (Chinese Glioma Genome Atlas), and Oncomine databases, we performed a series of analyses, such as gene expression, survival prognosis, DNA methylation, immune infiltration, and partner enrichment. We also utilized two glioma cell lines to conduct the colony formation and wound-healing assay.

Results

GAS2L3 gene was highly expressed in glioma tissues compared to nor

SUBMITTER: Zhao C 

PROVIDER: S-EPMC8026934 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature