An evaluation of inbreeding measures using a whole-genome sequenced cattle pedigree.

ABSTRACT: The estimation of the inbreeding coefficient (F) is essential for the study of inbreeding depression (ID) or for the management of populations under conservation. Several methods have been proposed to estimate the realized F using genetic markers, but it remains unclear which one should be used. Here we used whole-genome sequence data for 245 individuals from a Holstein cattle pedigree to empirically evaluate which estimators best capture homozygosity at variants causing ID, such as rare deleterious alleles or loci presenting heterozygote advantage and segregating at intermediate frequency. Estimators relying on the correlation between uniting gametes (F_UNI) or on the genomic relationships (F_GRM) presented the highest correlations with these variants. However, homozyg

SUBMITTER: Alemu SW 

PROVIDER: S-EPMC8027009 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature