TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance.

ABSTRACT: The perfect synchronization of maternal immune-endocrine mechanisms and those of the fetus is necessary for a successful pregnancy. In this report, decidual immune cells at the maternal-fetal interface were detected that expressed TIGIT (T cell immunoreceptor with Ig and ITIM domains), which is a co-inhibitory receptor that triggers immunological tolerance. We generated recombinant TIGIT-Fc fusion proteins by linking the extracellular domain of TIGIT and silent Fc fragments. The treatment with TIGIT-Fc of human decidual antigen presenting cells (APCs), the decidual dendritic cells (dDCs), and decidual macrophages (dMϕs) increased the production of interleukin 10 and induced the decidua APCs to powerfully polarize the decidual CD4⁺ T cells toward a classic T_H2 phenotyp

SUBMITTER: Fu W 

PROVIDER: S-EPMC8027249 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature