Genetic variability of human papillomavirus type 39 based on E6, E7 and L1 genes in Southwest China.

ABSTRACT:

Background

Human papillomavirus type 39 associated with genital intraepithelial neoplasia and invasive cancers, has a high prevalence in Southwest China. HPV E6, E7 are two main papillomavirus oncoproteins, closely relate to the function of HPV immortalization, cell transformation, and carcinogenesis. L1 is the major capsid protein, can reflect the replication status of the virus in cells and the progression of cervical lesions. The purpose of this study is to reveal the prevalence of HPV 39 and the genetic polymorphisms of HPV39 based on E6, E7 and L1 gene in southwest China.

Methods

Cell samples were collected by cervical scraped for HPV detecting and typing, and HPV39 positive samples were selected out. Important E6, E7 and L1 genes of HPV39 were sequenced and analyzed fo

SUBMITTER: He J 

PROVIDER: S-EPMC8027298 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature