Bevacizumab Treatment of Radiation-Induced Brain Necrosis: A Systematic Review.

ABSTRACT:

Background

Radiation brain necrosis (RBN) is a serious complication in patients receiving radiotherapy for intracranial disease. Many studies have investigated the efficacy and safety of bevacizumab in patients with RBN. In the present study, we systematically reviewed the medical literature for studies reporting the efficacy and safety of bevacizumab, as well as for studies comparing bevacizumab with corticosteroids.

Materials and methods

We searched PubMed, Cochrane library, EMBASE, and ClinicalTrials.gov from their inception through 1 March, 2020 for studies that evaluated the efficacy and safety of bevacizumab in patients with RBN. Two investigators independently performed the study selection, data extraction, and data synthesis.

Results

Overall, the present syste

SUBMITTER: Liao G 

PROVIDER: S-EPMC8027305 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature