Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity.

ABSTRACT: Virus-induced asthma is prevalent among children, but its underlying mechanisms are unclear. Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma. Nonetheless, the relationship between systemic virus infections, such as enterovirus infection, and the ensuing effects on allergic asthma development is unknown. Early-life enterovirus infection was correlated with higher risks of allergic diseases in children. Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period. Bone marrow-derived macrophages (BMDMs) from recovered EV-A71-infected mice showed sustained innate immune memory (trained immunity) that could drive naïve T helper cells toward Th2 an

SUBMITTER: Chen PC 

PROVIDER: S-EPMC8027667 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature