Circular RNA circMYBPC1 promotes skeletal muscle differentiation by targeting MyHC.

ABSTRACT: Skeletal muscle development is a complex and highly orchestrated biological process mediated by a series of myogenesis regulatory factors. Numerous studies have demonstrated that circular RNAs (circRNAs) are involved in muscle differentiation, but the exact molecular mechanisms involved remain unclear. Here, we analyzed the expression of circRNAs at the adult and embryo development stages of cattle musculus longissimus. A stringent set of 1,318 circRNAs candidates were identified, and we found that 495 circRNAs were differentially expressed between embryonic and adult tissue libraries. We subsequently focused on one of the most downregulated circRNAs (using the adult stage expression as control), and this was named muscle differentiation-associated circular RNA (circMYBPC1). With RN

SUBMITTER: Chen M 

PROVIDER: S-EPMC8027698 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature