A likelihood ratio approach for identifying three-quarter siblings in genetic databases.

ABSTRACT: The detection of family relationships in genetic databases is of interest in various scientific disciplines such as genetic epidemiology, population and conservation genetics, forensic science, and genealogical research. Nowadays, screening genetic databases for related individuals forms an important aspect of standard quality control procedures. Relatedness research is usually based on an allele sharing analysis of identity by state (IBS) or identity by descent (IBD) alleles. Existing IBS/IBD methods mainly aim to identify first-degree relationships (parent-offspring or full siblings) and second degree (half-siblings, avuncular, or grandparent-grandchild) pairs. Little attention has been paid to the detection of in-between first and second-degree relationships such as three-quarter siblin

SUBMITTER: Galvan-Femenia I 

PROVIDER: S-EPMC8027836 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature