Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy.

ABSTRACT: Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease worldwide. ω3-Fatty acids (ω3FAs) were found to attenuate kidney inflammation, glomerulosclerosis, and albuminuria in experimental and clinical studies of DN. As G protein-coupled receptor 120 (GPR120) was firstly identified as the receptor of ω3FAs, we here investigated the function of GPR120 in DN. We first examined the renal biopsies of DN patients, and found that GPR120 expression was negatively correlated with the progression of DN. Immunofluorescence staining analysis revealed that GPR120 protein was mainly located in the podocytes of the glomerulus. A potent and selective GPR120 agonist TUG-891 (35 mg · kg^-1 · d^-1, ig) was administered to db/db mice for 4 weeks. We showed that

SUBMITTER: Wei TT 

PROVIDER: S-EPMC8027848 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature