Mining the plasma-proteome associated genes in patients with gastro-esophageal cancers for biomarker discovery.

ABSTRACT: Gastro-esophageal (GE) cancers are one of the major causes of cancer-related death in the world. There is a need for novel biomarkers in the management of GE cancers, to yield predictive response to the available therapies. Our study aims to identify leading genes that are differentially regulated in patients with these cancers. We explored the expression data for those genes whose protein products can be detected in the plasma using the Cancer Genome Atlas to identify leading genes that are differentially regulated in patients with GE cancers. Our work predicted several candidates as potential biomarkers for distinct stages of GE cancers, including previously identified CST1, INHBA, STMN1, whose expression correlated with cancer recurrence, or resistance to adjuvant therapies or surgery.

SUBMITTER: Vizeacoumar FS 

PROVIDER: S-EPMC8027878 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature