Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study.

ABSTRACT:

Background

Host determinants of severe coronavirus disease 2019 include advanced age, comorbidities and male sex. Virologic factors may also be important in determining clinical outcome and transmission rates, but limited patient-level data is available.

Methods

We conducted an observational cohort study at seven public hospitals in Singapore. Clinical and laboratory data were collected and compared between individuals infected with different SARS-CoV-2 clades. Firth's logistic regression was used to examine the association between SARS-CoV-2 clade and development of hypoxia, and quasi-Poisson regression to compare transmission rates. Plasma samples were tested for immune mediator levels and the kinetics of viral replication in cell culture were compared.

Findings

319

SUBMITTER: Young BE 

PROVIDER: S-EPMC8027908 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature