Aging-associated skeletal muscle defects in HER2/Neu transgenic mammary tumor model.

ABSTRACT:

Background

Loss of skeletal muscle volume and resulting in functional limitations are poor prognostic markers in breast cancer patients. Several molecular defects in skeletal muscle including reduced MyoD levels and increased protein turn over due to enhanced proteosomal activity have been suggested as causes of skeletal muscle loss in cancer patients. However, it is unknown whether molecular defects in skeletal muscle are dependent on tumor etiology.

Methods

We characterized functional and molecular defects of skeletal muscle in MMTV-Neu (Neu+) mice (n= 6-12), an animal model that represents HER2+ human breast cancer, and compared the results with well-characterized luminal B breast cancer model MMTV-PyMT (PyMT+). Functional studies such as grip strength, rotarod performanc

SUBMITTER: Wang R 

PROVIDER: S-EPMC8028024 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature