Multi-Omic Single-Shot Technology for Integrated Proteome and Lipidome Analysis.

ABSTRACT: Mass spectrometry (MS) serves as the centerpiece technology for proteome, lipidome, and metabolome analysis. To gain a better understanding of the multifaceted networks of myriad regulatory layers in complex organisms, integration of different multiomic layers is increasingly performed, including joint extraction methods of diverse biomolecular classes and comprehensive data analyses of different omics. Despite the versatility of MS systems, fractured methodology drives nearly all MS laboratories to specialize in analysis of a single ome at the exclusion of the others. Although liquid chromatography-mass spectrometry (LC-MS) analysis is similar for different biomolecular classes, the integration on the instrument level is lagging behind. The recent advancements in high flow proteomics enab

SUBMITTER: He Y 

PROVIDER: S-EPMC8028036 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature