Clusterin contributes to early stage of Alzheimer's disease pathogenesis.

ABSTRACT: While clusterin is reportedly involved in Alzheimer's disease (AD) pathogenesis, how clusterin interacts with amyloid-β (Aß) to cause Aß neurotoxicity remains unclear in vivo. Using 5×FAD transgenic mice, which develop robust AD pathology and memory deficits when very young, we detected interactions between clusterin and Aß in the mouse brains. The two proteins were concurrently upregulated and bound or colocalized with each other in the same complexes or in amyloid plaques. Neuropathology and cognitive performance were assessed in the progeny of clusterin-null mice crossed with 5×FAD mice, yielding clu^-/- ;5×FAD and clu^+/+ ;5×FAD. We found far less of the various pools of Aß proteins, most strikingly soluble Aß oligomers and amyloid plaques in clu^-/- ;5×FA

SUBMITTER: Oh SB 

PROVIDER: S-EPMC8028273 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature