A clinical and histopathological study of malformations observed in fetuses infected by the Zika virus.

ABSTRACT:

Background

The recent outbreak of Zika virus (ZIKV) infection and the associated increased prevalence of microcephaly in Brazil underline the impact of viral infections on embryo fetal development. The aim of the present study is to provide a detailed clinical and histopathological study of the fetal disruption caused by the ZIKV, with a special focus on the associated neuropathological findings.

Methods

A detailed feto-placental examination, as well as neuropathological and neurobiological studies were performed on three fetuses collected after pregnancy termination between 22 and 25 weeks of gestation (WG), because brain malformations associated with a maternal and fetal ZIKV infection was diagnosed.

Results

In all three cases, the maternal infection occurred during

SUBMITTER: Beaufrere A 

PROVIDER: S-EPMC8028325 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature