Integrated molecular landscape of amyotrophic lateral sclerosis provides insights into disease etiology.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a severe, progressive and ultimately fatal motor neuron disease caused by a combination of genetic and environmental factors, but its underlying mechanisms are largely unknown. To gain insight into the etiology of ALS, we here conducted genetic network and literature analyses of the top-ranked findings from six genome-wide association studies of sporadic ALS (involving 3589 cases and 8577 controls) as well as genes implicated in ALS etiology through other evidence, including familial ALS candidate gene association studies. We integrated these findings into a molecular landscape of ALS that allowed the identification of three main processes that interact with each other and are crucial to maintain axonal functionality, especially of the long axons of m

SUBMITTER: Klemann CJHM 

PROVIDER: S-EPMC8028446 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature