Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease.

ABSTRACT: Aβ immunization of Alzheimer's disease (AD) patients in the AN1792 (Elan Pharmaceuticals) trial caused Aβ removal and a decreased density of neurons in the cerebral cortex. As preservation of neurons may be a critical determinant of outcome after Aβ immunization, we have assessed the impact of previous Aβ immunization on the expression of a range of apoptotic proteins in post-mortem human brain tissue. Cortex from 13 AD patients immunized with AN1792 (iAD) and from 27 nonimmunized AD (cAD) cases was immunolabeled for proapoptotic proteins implicated in AD pathophysiology: phosphorylated c-Jun N-terminal kinase (pJNK), activated caspase3 (a-casp3), phosphorylated GSK3β on tyrosine 216 (GSK3β_tyr216 ), p53 and Cdk5/p35. Expression of these proteins was analyzed in relation to immun

SUBMITTER: Paquet C 

PROVIDER: S-EPMC8028546 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature