Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.

ABSTRACT: Protein misfolding diseases refer to a variety of disorders that develop as a consequence of the misfolding of proteins in various organs. The etiologies of Parkinson's and Alzheimer's disease remain unclear, but it seems that type two diabetes and other prediabetic states could contribute to the appearance of the sporadic forms of these diseases. In addition to amylin deposition, other amyloidogenic proteins implicated in the pathophysiology of neurodegenerative diseases could have important roles in the pathogenesis of this disease. As we have previously demonstrated the presence of α-synuclein deposits in the pancreas of patients with synucleinopathies, as well as tau and Aβ deposits in the pancreatic tissue of Alzheimer's disease patients, we studied the immunoreactivity of amylin, tau

SUBMITTER: Martinez-Valbuena I 

PROVIDER: S-EPMC8028740 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature