Overexpression of DSCR1 prevents proliferation and predicts favorable prognosis in colorectal cancer patients.

ABSTRACT:

Objectives

Down syndrome critical region 1 (DSCR1) is associated with carcinogenesis and tumor growth in several types of malignancy. However, little is known about the role of DSCR1 in CRC progression. The present study aimed to elucidate the clinicopathological significance, prognostic, and function roles of DSCR1 in CRC.

Methods

Firstly, we analyzed DSCR1 expression in 58 paired CRC samples and Oncomine database. Then, we analyzed DSCR1 expression in two independent CRC cohorts (test cohort: n = 70; validation cohort: n = 58) and tested its overall survival (OS) by Kaplan-Meier survival analyses. Finally, we overexpressed DSCR1 in two CRC cell lines DLD1 and LoVo and analyzed its effect on cell cycle and senescence.

Results

DSCR1 expression was significantly decrea

SUBMITTER: Li WX 

PROVIDER: S-EPMC8028816 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature