Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia.

ABSTRACT: Collateral blood flow as vascular adaptions to focal cerebral ischemia is well recognized. However, few studies directly investigate the dynamics of collateral vessel recruitment in vivo and little is known about the effect of collateral blood flow in different cerebrovascular hierarchy on the neuropathology after focal ischemic stroke. Here, we report that collateral blood flow is critically involved in blood vessel compensations following regional ischemia. We occluded a pial arteriole using femtosecond laser ablating under the intact thinned skull and documented the changes of collateral flow around the surface communication network and between the surface communication network and subsurface microcirculation network using in vivo two photon microscopy imaging. Occlusion of the pial art

SUBMITTER: Luo C 

PROVIDER: S-EPMC8028906 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature