Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine.

ABSTRACT: Age-related neurodegenerative diseases such as Alzheimer's disease (AD) are distressing conditions causing countless levels of suffering for which treatment is often insufficient or inexistent. Considered to be the most common cause of dementia and an incurable, progressive neurodegenerative disorder, the intricate pathogenic mechanisms of AD continue to be revealed and, consequently, an effective treatment needs to be developed. Among the diverse hypothesis that have been proposed to explain AD pathogenesis, the one concerning mitochondrial dysfunction has raised as one of the most discussed with an actual acceptance in the field. It posits that manipulating mitochondrial function and understanding the deficits that result in mitochondrial injury may help to control and/or limit the devel

SUBMITTER: Cardoso S 

PROVIDER: S-EPMC8028979 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature