Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease.

ABSTRACT: Causative treatment strategies for Parkinson's disease (PD) will have to address multiple underlying pathomechanisms to attenuate neurodegeneration. Additionally, the intrinsic regenerative capacity of the central nervous system is also an important factor contributing to restoration. Extracellular cues can limit sprouting and regrowth of adult neurons, but even aged neurons have a low intrinsic regeneration capacity. Whether this capacity has been lost or if growth inhibitory cues are increased during PD progression has not been resolved yet. In this study, we assessed the regenerative potential in the nigrostriatal system in post-mortem brain sections of PD patients compared to age-matched and young controls. Investigation of the expression pattern of the regeneration-associated protein

SUBMITTER: Saal KA 

PROVIDER: S-EPMC8029215 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature