The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor.

ABSTRACT: There are over 120 types of brain tumor and approximately 45% of primary brain tumors are gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a median survival rate of 14 months. Despite progress in our knowledge, current therapies are unable to effectively combat primary brain tumors and patient survival remains poor. Tumor metabolism is important to consider in therapeutic approaches and is the focus of numerous research investigations. Lactate dehydrogenase A (LDHA) is a cytosolic enzyme, predominantly involved in anaerobic and aerobic glycolysis (the Warburg effect); however, it has multiple additional functions in non-neoplastic and neoplastic tissues, which are not commonly known or discussed. This review summarizes what is currently known about the

SUBMITTER: Valvona CJ 

PROVIDER: S-EPMC8029296 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature