Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles.

ABSTRACT: Melanotic tumors of the nervous system show overlapping histological characteristics but differ substantially in their biological behavior. In order to achieve a better delineation of such tumors, we performed an in-depth molecular characterization. Eighteen melanocytomas, 12 melanomas, and 14 melanotic and 14 conventional schwannomas (control group) were investigated for methylome patterns (450k array), gene mutations associated with melanotic tumors and copy number variants (CNVs). The methylome fingerprints assigned tumors to entity-specific groups. Methylation groups also showed a substantial overlap with histology-based diagnosis suggesting that they represent true biological entities. On the molecular level, melanotic schwannomas were characterized by a complex karyotype with recurre

SUBMITTER: Koelsche C 

PROVIDER: S-EPMC8029316 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature