Chromogranin A-positive hormone-negative endocrine cells in pancreas in human pregnancy.

ABSTRACT:

Introduction

We sought to determine whether chromogranin A-positive hormone-negative (CPHN) endocrine cells are increased in the pancreas of pregnant women, offering potential evidence in support of neogenesis.

Methods

Autopsy pancreata from pregnant women (n = 14) and age-matched non-pregnant control women (n = 9) were obtained. Staining of pancreatic sections for chromogranin A, insulin and a cocktail of glucagon, somatostatin, pancreatic polypeptide and ghrelin was undertaken, with subsequent evaluation for CPHN cell frequency.

Results

The frequency of clustered β-cells was increased in pregnant compared to non-pregnant subjects (46.6 ± 5.0 vs. 31.8 ± 5.0% clustered β-cells of total clustered endocrine cells, pregnant vs. non-pregnant, p < .05)

SUBMITTER: Moin ASM 

PROVIDER: S-EPMC8029563 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature